Muscular activity and choline esterase

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The Choline-esterase Activity of the Blood Serum in Disease.

The investigations of Dale and his coworkers (1, 2) on the chemical transmission of parasympathetic nerve stimulation and of Walker (3, 4) on the use of physostigmine and prostigmin in myasthenia gravis have stimulated interest in the choline-esterase activity of serum. Lucas, Hall, and Ettinger (5) studied the serum esterase activity of 200 subjects and obtained results that were in essential ...

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Studies on the Specificity of Choline Esterase

The present investigation was undertaken to determine the relation between the structure of various substrates and the action of serum choline esterase upon them. The comparison of activities with different esters should take into account two factors : the hydrolytic velocities compared should be linear functions of time, and these velocities should be independent of substrate concentration. Th...

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On The Physiological Significance of Choline Esterase *

During the last 20 years evidence has accumulated, mainly from the work of 0. Loewi, Dale, Cannon and their co-workers, supporting the view that the action of sympathetic and parasympathetic nerves on the effector organ occurs by virtue of chemical mediation. It is generally believed that adrenaline, or a related substance, sympathin, is the transmitter substance at sympathetic nerve endings, w...

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Cccv. the Purification of Choline-esterase

ALTHOUGH it was previously known from pharmacological experiments, quoted in our earlier papers, that certain body fluids brought about the enzymic decomposition of small amounts of acetylcholine, the first demonstration of the existence of a specific enzyme which catalyses the hydrolysis of this ester, as well as of other esters of choline, was that of Stedman et al. [1932] who termed the enzy...

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Electric Potential and Activity of Choline Esterase in the Electric Organ of Electrophorus Electricus (linnaeus)

1. If the concentration of choline esterase is determined at different sections from the head to the caudal end of the electric organ of Electrophorus electricus (Linneaus) S-like curves are obtained. These curves are essentially the same as those which show the number of electric discs per centimeter and the E.M.F. per centimeter. 2. In the organ of Hunter the concentration of the enzyme does ...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 1943

ISSN: 0022-3751

DOI: 10.1113/jphysiol.1943.sp004024